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Famotidine Does Not Inhibit Liver Regeneration

 

作者: R. Kanashima,   M. Kobayashi,  

 

期刊: European Surgical Research  (Karger Available online 1989)
卷期: Volume 21, issue 3-4  

页码: 190-195

 

ISSN:0014-312X

 

年代: 1989

 

DOI:10.1159/000129023

 

出版商: S. Karger AG

 

关键词: H2-receptor antagonist;Famotidine;Liver regeneration

 

数据来源: Karger

 

摘要:

The H2-blockers, cimetidine and ranitidine, are reported to inhibit liver regeneration. In this work, the effects of a new powerful H2-receptor antagonist, famotidine, on liver regeneration were studied in rats. The animals were divided into three groups: group I in which a standard two-thirds hepatectomy was performed, group II in which the rats were treated with famotidine (intramuscular dose of 0.8 mg/kg body weight) on the day of operation and 24 and 48 h after hepatectomy, and group III in which the animals were intramuscularly injected with a larger dose of famotidine (1.2 mg/kg body weight) in the same way as group II. The histology and mitotic index of remnant livers and serum levels of aminotransferase and albumin were examined from 24 h to 10 days after the operation. The treatment with famotidine (groups II and III) did not inhibit hepatocyte mitosis but, on the contrary, raised the index on day 3 after hepatectomy when compared with the controls (group I). The albumin synthesis was well preserved in the famotidine-treated animals. The noninhibitory effects of famotidine on liver regeneration are discussed.

 

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