Famotidine Does Not Inhibit Liver Regeneration
作者:
R. Kanashima,
M. Kobayashi,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 3-4
页码: 190-195
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129023
出版商: S. Karger AG
关键词: H2-receptor antagonist;Famotidine;Liver regeneration
数据来源: Karger
摘要:
The H2-blockers, cimetidine and ranitidine, are reported to inhibit liver regeneration. In this work, the effects of a new powerful H2-receptor antagonist, famotidine, on liver regeneration were studied in rats. The animals were divided into three groups: group I in which a standard two-thirds hepatectomy was performed, group II in which the rats were treated with famotidine (intramuscular dose of 0.8 mg/kg body weight) on the day of operation and 24 and 48 h after hepatectomy, and group III in which the animals were intramuscularly injected with a larger dose of famotidine (1.2 mg/kg body weight) in the same way as group II. The histology and mitotic index of remnant livers and serum levels of aminotransferase and albumin were examined from 24 h to 10 days after the operation. The treatment with famotidine (groups II and III) did not inhibit hepatocyte mitosis but, on the contrary, raised the index on day 3 after hepatectomy when compared with the controls (group I). The albumin synthesis was well preserved in the famotidine-treated animals. The noninhibitory effects of famotidine on liver regeneration are discussed.
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