The long-term maintenance treatment of schizophrenic out-patients with depot flupenthixol
作者:
CarneyM. W.P.,
SheffieldB. F.,
期刊:
Current Medical Research and Opinion
(Taylor Available online 1973)
卷期:
Volume 1,
issue 7
页码: 423-426
ISSN:0300-7995
年代: 1973
DOI:10.1185/03007997309111704
出版商: Taylor&Francis
关键词: Tranquillizing agents;flupenthixol;schizophrenia;long-term care
数据来源: Taylor
摘要:
SummaryAfter initial stabilisation, flupenthixol decanoate injections were given to 134 outpatient schizophrenics over a period of 28 months. Thirty percent showed extrapyramidal side-effects and 8% severe depression. Persistent anergia and hypomania were also seen. There was a significant reduction in adapted Wing's scale scores over 6 months in the first 56 patients. Severe and unpredictable extra-pyramidal side-effects were less frequent than with fluphenazine, the relapse rate among aggressive paranoid schizophrenics tending to be higher with flupenthixol. Flupenthixol-treated patients seemed more active, sociable and able to communicate than phenothiazine-treated patients, which helped in their rehabilitation. No toxic effects were seen. Flupenthixol is considered to be an effective anti-psychotic and suitable for out-patient stabilisation and maintenance therapy.
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