Regulation of sterol synthesis in human intestinal mucosa
作者:
D. J. BETTERIDGE,
W. KRONE,
CAROLE MIDDLETON,
D. J. GALTON,
期刊:
European Journal of Clinical Investigation
(WILEY Available online 1971)
卷期:
Volume 1,
issue 4
页码: 227-230
ISSN:0014-2972
年代: 1971
DOI:10.1111/j.1365-2362.1971.tb00621.x
出版商: Blackwell Publishing Ltd
关键词: Human jejunal mucosa;sterol synthesis;cholesterol;cholestyramine;chenodeoxycholic acid;familial hypercholesterolaemia.
数据来源: WILEY
摘要:
AbstractThe effect of dietary factors and experimental manipulations designed to perturb the entero‐hepatic circulation on the rate of sterol synthesis were studied in freshly isolated human jejunal mucosa from normal subjects.Fasting significantly reduced the rate of sterol synthesis from [14C] acetate in jejunal mucosa obtained from normolipaemic obese subjects. A high cholesterol diet had no consistenteffect onthe synthesis in normal subjects. Administration of cholestyramine resulted in a marked rise in the incorporation of [l4C] acetate into sterols, while the administration of chenodeoxycholic acid did not significantly reduce basal sterol synthesis in normal subjects.These results demonstrate that in man the rate of sterol synthesis in intestinal mucosa is altered in response to physiological variables. Although these findings indicate that sterol synthesis in this tissue is subject to regulation, no difference was observed in basal sterol synthesis between normal subjects and patients heterozygous for familial hypercholesterolaemi
点击下载:
PDF
(372KB)
返 回