A method for the assay of topical corticosteroids*
作者:
R. MARKS,
D. PONGSEHIRUN,
T. SAYLAN,
期刊:
British Journal of Dermatology
(WILEY Available online 1973)
卷期:
Volume 88,
issue 1
页码: 69-74
ISSN:0007-0963
年代: 1973
DOI:10.1111/j.1365-2133.1973.tb06674.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYThe dorsal skin of the hairless mouse when ‘stripped’ with sticky tape proved to be a suitable model for a study of the antimitotic effect of betamethasone‐17‐valerate and hydrocortisone. The application of 1%, betamethasone‐17‐valerate and 1%, hydrocortisone creams under occlusive dressings for 24 h produced a three‐ to four‐fold drop in the colcemid‐induced mitotic index as compared to a control application.The antimitotic effect of the betamethasone‐17‐valerate preparation started at or before 5 h and continued for at least 4 days after removal of the active material. It was shown in addition, that 1% betamethasone‐17‐valerate also reduced the number of cells entering DNA synthesis. The antimitotic effect of hydrocortisone was detected at a concentration of 10‐2and that of betamethasone‐17‐valerate was detected at a concentration of 10‐4. It is suggested that the animal model used is a useful one for assaying the potency of
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