Interaction between Parathyroid Hormone and Catecholamines on Renal Cortical Cyclic AMP
作者:
Kiyoshi Kurokawa,
Gregory Lenchner,
Shaul G. Massry,
期刊:
Nephron
(Karger Available online 1977)
卷期:
Volume 18,
issue 1
页码: 60-67
ISSN:1660-8151
年代: 1977
DOI:10.1159/000180767
出版商: S. Karger AG
关键词: Parathyroid hormone;Isoproterenol;Norepinephrine;cAMP;Adrenergic blocking agents;Renal gluconeogenesis
数据来源: Karger
摘要:
Parathyroid hormone (PTH) and catecholamines (CA) increased cAMP levels in isolated tubules of rat renal cortex. A rise in cAMP could be detected 10 sec after the addition of agonists, and it reached the peak in 30–60 sec and then decreased despite the presence of active agonists. Direct relationships exist between theophylline concentrations and cAMP levels in response to agonists. Three- to fivefold rises in cAMP levels were observed with a maximal dose of PTH compared with that of CA, and there was no additive effect. Both PTH and CA stimulated renal gluconeogenesis; when added together with each maximal dose, no additive effect was observed. These results suggest the important role of phosphodiesterase to control tubular cAMP in response to hormonal stimuli, and there is a tubule cell group responding to both PTH and C
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