Immunohistochemical Distribution of Endothelin in Biopsies of Pediatric Nephrotic Syndrome
作者:
Luisa Murer,
Graziella Zacchello,
Giuseppe Basso,
Alessandra Scarpa,
Giovanni Montini,
Maria Laura Chiozza,
Franco Zacchello,
期刊:
American Journal of Nephrology
(Karger Available online 1994)
卷期:
Volume 14,
issue 3
页码: 157-161
ISSN:0250-8095
年代: 1994
DOI:10.1159/000168707
出版商: S. Karger AG
关键词: Endothelin;Nephrotic syndrome;Children;Renal biopsies
数据来源: Karger
摘要:
In a retrospective, double-blind study, we analyzed, utilizing an immunohistochemical technique, the distribution of Endothelin (Et) in 20 renal biopsies of 17 children with nephrotic syndrome (NS): 9 cases of steroid-responsive and 8 of steroid-resistant minimal-change disease (MCD) and 3 cases of focal segmental glomerulosclerosis (FSGS). Thirteen out of 20 biopsies (9/9 steroid-responsive MCD and 4/8 steroid-resistant MCD) showed a weak positivity of the vascular endothelial cells, as the normal renal tissue samples obtained from tumor nephrectomies. Seven out of 20 biopsies, all steroid-resistant NS, showed a marked positivity of the vascular endothelium and of the tubules and/or interstitial cells. In 4 of these 7 cases (1 MCD, 3 FSGS) a positivity of glomeruli was also revealed. The positivity of vascular endothelium seems to confirm its central role in Et production. The marked immunoreactivity detected in the endothelial cells and other renal components reveals a local increase in Et in some steroid-resistant MCD and, particularly, in FSGS. These preliminary observations suggest that Et may participate (cause or epiphenomon) in the mechanisms underlying the development of glomerulosclerosis and the progression of renal damage.
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