GM-CSF Treatment in Aplasia after Cytotoxic Therapy
作者:
C. Gattringer,
J. Thaler,
J. Drach,
M. Micksche,
H. Huber,
期刊:
Onkologie
(Karger Available online 1989)
卷期:
Volume 12,
issue 1
页码: 16-18
ISSN:0378-584X
年代: 1989
DOI:10.1159/000216590
出版商: S. Karger GmbH
关键词: GM-CSF;Chemotherapy-induced Aplasia;AML
数据来源: Karger
摘要:
GM-CSF was used to overcome fatal myelosuppression after cytotoxic chemotherapy. Two different application modalities were compared: a continuous 24 h infusion was more effective compared to a 30 min short term infusion. Using the former modality at a dose of 10 μg/kg/d for five days very impressive responses were observed. No major side effects did occur. The first 13 patients treated in this way included 8 AML cases. Only one of these latter patients had a leukemia relapse. However, in this patient the immediate GM-CSF response was clearly separated from the relapse occurring later in the observation period. Thus, the preliminary results of the present paper suggest that GM-CSF besides of being very efficient in accelerating granulocyte recovery does not stimulate the growth of AML blasts in vivo in patients with only minimal residual disease
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