Possible role of T cells in the establishment of IgG plasma cell‐rich periodontal lesion –Augmentation of IgG synthesis in the polyclonal B cell activation response by autoreactive T cells
作者:
Hiroö Ito,
Yasushi Harada,
Takashi Matsuo,
Shigeyuki Ebisu,
Hiroshi Okada,
期刊:
Journal of Periodontal Research
(WILEY Available online 1988)
卷期:
Volume 23,
issue 1
页码: 39-45
ISSN:0022-3484
年代: 1988
DOI:10.1111/j.1600-0765.1988.tb01025.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
The effect of T cells on T‐independent polyclonal B cell activation (PBA) was studied in vitro in mice. Helper/inducer T cells were activated by interaction with la antigens expressed on B cells. The activated T cells enhanced IgG synthesis in the PBA reaction. la antigen expression on B cells increased when stimulated by polyclonal B cell activators. An autoreactive T cell line was established by longterm culture of spleen cells with polyclonal B cell activators. The culture supernatant from this autoreactive T cell line enhanced IgG synthesis in PBA. The above results suggest that autoreactive T cells were activated by la expressed on B cells stimulated with polyclonal B cell activators, and then prompted B cells to synthesize IgG. Therefore, autoreactive T cells may play an important role in the establishment of the IgG plasma cell‐rich periodontal les
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