Experimentally‐induced irritant contact dermatitis
作者:
Carolyn M. Willis,
Catherine J. M. Stephens,
J. D. Wilkinson,
期刊:
Contact Dermatitis
(WILEY Available online 1988)
卷期:
Volume 18,
issue 1
页码: 20-24
ISSN:0105-1873
年代: 1988
DOI:10.1111/j.1600-0536.1988.tb05484.x
出版商: Blackwell Publishing Ltd
关键词: Irritant contact dermatitis;benzalkonium chloride;sodium lauryl sulphate;croton oil;dithranol;nonanoic acid;propylene glycol;sodium hydroxide
数据来源: WILEY
摘要:
Patch testing with 7 irritants has been performed on a panel of 42 health volunteers, with the aim of determining concentrations which would induce mild to moderate reactions in at least 75% of individuals tested. The irritants studied and their optimum concentrations were as follows: benzalkonium chloride, 0.5%; sodium lauryl sulphate, 5%; croton oil, 0.8%; dithranol, 0.02%; nonanoic acid, 80%; propylene glycol, 100%; sodium hydroxide, 2%. Responder rates lower than 75% had to be accepted for benzalkonium chloride and sodium hydroxide in order to prevent overly severe reactions, whilst propylene glycol proved to have only marginal irritant properties.
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