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Inhibitory effects of ergosterol isolated from the edible mushroomHypsizigus marmoreuson TPA‐induced inflammatory ear oedema and tumour promotion in mice

 

作者: Ken Yasukawa,   Takashi Aoki,   Michio Takido,   Tetsuro Ikekawa,   Hideharu Saito,   Tsunetomo Matsuzawa,  

 

期刊: Phytotherapy Research  （WILEY Available online 1994）
卷期: Volume 8, issue 1  

页码: 10-13

 

ISSN:0951-418X

 

年代: 1994

 

DOI:10.1002/ptr.2650080103

 

出版商: John Wiley&Sons, Ltd.

 

关键词: edible mushroom;Hypsizigus marmoreus;ergosterol;TPA‐induced tumour promotion;antitumour promotion

 

数据来源: WILEY

 

摘要:

AbstractAn antitumour‐promoting activity in two‐stage carcinogenesis, was found in the methanol and ethyl acetate extracts of the Japanese edible mushroom ‘Buna‐shimeji’,Hypsizigus marmoreus(Tricholomataceae). From the active fractions of the extracts, two sterols, ergosterol and ergosterol peroxide, were isolated. The isolates showed inhibitory activity against 12‐O‐tetradecanoylphorbol‐13‐acetate induced ear inflammation in mice, and ergosterol markedly inhibited tumour promotion in a two‐stage carcinogenesis experiment. These sterols may be useful in developing an effective method o

 

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