Inhibition of the Plasminogen Activator Urokinase by Alpha-Tocopherol
作者:
D. Ogston,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 67,
issue 2
页码: 114-118
ISSN:0001-5792
年代: 1982
DOI:10.1159/000207036
出版商: S. Karger AG
关键词: α-Tocopherol;Inhibition of urokinase
数据来源: Karger
摘要:
α-Tocopherol (vitamin E) inhibited the activity of urokinase on fibrin plates and on the amidolytic substrate S-2444 in a concentration- and time-dependent manner. Inhibition was not removed by dialysis. In the presence of dilutions of plasma, protein-containing fractions of gel-filtered plasma, or bovine serum albumin, the inhibition of urokinase by α-tocopherol was abolished. Urokinase activity was not inhibited by phytol, menadione or hydroquinon
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