Stereoselective Suppression of Neutrophil Function by Ketamine?
作者:
WeissM.,
BirkhahnA.,
MettlerS.,
SchneiderM.,
WemetP.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1995)
卷期:
Volume 17,
issue 1
页码: 91-107
ISSN:0892-3973
年代: 1995
DOI:10.3109/08923979509052723
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThe effects of the commercially available ketamine preparation (Ketanest™). the ketamine racemate and of the two enantiomers, the R(-)-racemate and the S(+)-racemate, as well as its drug-free solvent were examined by N-formyl-methionyl-leucyl-phenylalanine-(FMLP)- and zymosan-induced oxygen radical production of polymorphonuclear cells (PMN). The racemate and the two enantiomers of ketamine suppressed FMLP- and zymosan-induced chemiluminescence of PMN in a dose-dependent fashion to the Same extent. Therefore suppression of chemiluminescence of PMN by ketamine does not result from a specific receptor interaction.
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