Blood and Urinary Concentrations of Fosfomycin as a Function of the Renal Function Value
作者:
M. Neuman,
G. Fluteau,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 1
页码: 196-199
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222047
出版商: S. Karger AG
关键词: Fosfomycin;Urinary concentration;Renal function
数据来源: Karger
摘要:
The following parameters were considered in studying 43 subjects under treatment for urinary infections with different degrees of renal insufficiency: the maximum blood concentrations, the plasmatic half-life, and the urinary concentrations of fosfomycin as a function of the plasma creatinine of the subject treated. The curve of the average maximum blood concentrations show a parabola-like increase, the plasmatic half-life followed the same tendency, while the curve of the average urinary concentrations presented an exponential decrease. The urinary concentrations were, nevertheless, always higher than 100 μg/ml regardless of the degree of renal insufficiency and even in the subjects who had a very high plasma creatinine. Given its absence of renal and systemic toxicity, the daily dosage of fosfomycin could remain unchanged regardless of the degree of insuffiziency
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