Lowered Glutathione‐Peroxidase Activity in Asthmatic Patients with Food and Aspirin Intolerance
作者:
R. Malmgren,
G. Unge,
O. Zetterströ,
H. Theorell,
K. Wahl,
期刊:
Allergy
(WILEY Available online 1986)
卷期:
Volume 41,
issue 1
页码: 43-45
ISSN:0105-4538
年代: 1986
DOI:10.1111/j.1398-9995.1986.tb00273.x
出版商: Blackwell Publishing Ltd
关键词: aspirin intolerance;GSH‐Px
数据来源: WILEY
摘要:
In analogy with findings from animal experiments, people with low glutathione‐peroxidase (GSH‐Px) activity could be expected to have altered sensitivities to effects of drugs, chemicals and possibly food. We have investigated GSH‐Px activity in 12 patients with intrinsic asthma and food and aspirin intolerance. Ten of the 12 patients had very low or low GSH‐Px activity and the frequency of low GSH‐Px activity in this group was statistically significant (P<0.001) compared with the control material of age‐ and sex‐matched healthy individuals. Our finding of lowered GSH‐Px activity in patients with aspirin intolerance may indicate the involvement of hitherto unknown mechanisms in the pathogenesis of asth
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