5-Fluorouracil, Adriamycin, Cyclophosphamide (FAC) vs. 5-Fluorouracil, Epirubicin, Cyclophosphamide (FEC) in Metastatic Breast Cancer
作者:
Massimo Lopez,
Paola Papaldo,
Luigi Di Lauro,
Patrizia Vici,
Silvia Carpano,
Ettore M.S. Conti,
期刊:
Oncology
(Karger Available online 1989)
卷期:
Volume 46,
issue 1
页码: 1-5
ISSN:0030-2414
年代: 1989
DOI:10.1159/000226671
出版商: S. Karger AG
关键词: Chemotherapy;Epirubicin;Breast cancer
数据来源: Karger
摘要:
94 evaluable patients with metastatic breast cancer were randomly assigned to 5-fiuorouracil, adriamycin, and cyclophosphamide (FAC) or 5-fluorouracil, epirubicin, and cyclophosphamide (FEC), with cycles repeated every 3 weeks. The objective response rate to FAC was 46% versus 44% to FEC. There was no significant difference in the median duration of response and median survival for the two regimens. Toxicity was more frequent and more pronounced in patients receiving FAC. Results indicate therapeutic equivalence of the two regimens and reduced toxicity of the epirubicin arm.
点击下载:
PDF
(1768KB)
返 回