Model of Pulmonary Extravasation as an Effect of Neutropenia in Endotoxic Shock in Guinea Pigs
作者:
Lena Mårtensson,
B. Davidsson,
Ursula Hultkvist,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 6
页码: 319-326
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129045
出版商: S. Karger AG
关键词: Pulmonary extravasation;Neutrophil;Endotoxemia;Guinea pig
数据来源: Karger
摘要:
A guinea pig model was developed to document the association of polymorphonuclear neutrophils (PMN) decrease with pulmonary leakage after a sublethal infusion of endotoxin (LPS Escherichia coli 0111:B4, 5 µg/min/kg). A control group was prepared in the same manner and given an infusion of vehicle alone. Severe leukopenia developed, mostly expressed in the neutrophil population. There was a decrease in RBC catalase and fibronectin. Plasma leakage in the lung followed the endotoxin infusion, which could indicate endothelial cell damage. The results from the present study suggest an activation of PMN in endotoxin-infused animals, degranulation and release of toxic oxygen species, resulting in pulmonary plasma extravasation
点击下载:
PDF
(1096KB)
返 回