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Effect of a Single Nighttime Dose of Oxazepam on Seizure Duration in Electroconvulsive Therapy

 

作者: Anders Olesen,   Anette Lolk,   Peder Christensen,  

 

期刊: Convulsive Therapy  (OVID Available online 1989)
卷期: Volume 5, issue 1  

页码: 3-7

 

ISSN:0749-8055

 

年代: 1989

 

出版商: OVID

 

关键词: Electroconvulsive therapy;Seizure duration;Benzo-diazepine;Oxazepam

 

数据来源: OVID

 

摘要:

In a double-blind crossover study, 12 depressed inpatients receiving bilateral electroconvulsive therapy (ECT) were given 22.5 mg oxazepam or placebo (identical tablets, randomized order) the night before treatment. Seizure duration was measured using the cuff method and a total of 20 pairs of measurements were made. Mean duration after oxazepam administration was 0.9 s longer than after placebo; this difference was not statistically significant. The relevant lower one-sided 95% confidence limit was −4.1 s. Single administration of oxazepam, 22.5 mg, has little average effect on seizure duration in ECT.

 

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