Application of Immunohistochemistry to the Isolated Mucosa of the Mouse Gastrointestinal Tract, with Special Reference to Somatostatin Cells
作者:
Y. Satoh,
Y. Oomori,
K. Ishikawa,
T. Satoh,
K. Ono,
期刊:
Cells Tissues Organs
(Karger Available online 1988)
卷期:
Volume 133,
issue 3
页码: 229-233
ISSN:1422-6405
年代: 1988
DOI:10.1159/000146645
出版商: S. Karger AG
关键词: Somatostatin;Gastrointestinal tract;Isolated mucosa;Mice
数据来源: Karger
摘要:
In the present study, in order to easily grasp whole images of somatostatin (D) cells, the isolated mucosa of the mouse gastrointestinal tract was immunohistochemically treated. The present study revealed that: (1) in the stomach, small-intestinal villi and colon, about 20% of the D cells extrude basal cytoplasmic processes, showing terminal expansions in many cases; on the other hand, in the crypts of the small intestine, few D cells possess basal processes, and (2) in the stomach, there is no determined tendency in the direction of the basal processes of the D cells; on the other hand, in the small-intestinal villi and colon, most D cell basal processes run toward the villus base and colon crypt bottoms. The direction of the basal processes of the D cells in the gastrointestinal tract seems to be mostly in favor of the migration pattern of epithelial cells described previously. It is likely that, if the targets of the D cells are near the D cells the basal process is not necessary for local secretion of somatostatin. During migration however, D cells might extrude basal processes to keep relationships with their targets.
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