Clinicopathologic study of primary mediastinal non‐lymphoblastic non‐Hodgkin's lymphomas among the Japanese
作者:
Atsuko Nakagawa,
Shigeo Nakamura,
Takashi Koshikawa,
Atsuo Nakayama,
Tetsuro Nagasaka,
Tadashi Motoori,
Masaru Kojima,
Yasuo Hosomura,
Ryuzo Ueda,
Shigeo Mori,
Junpei Asai,
Taizan Suchi,
期刊:
Pathology International
(WILEY Available online 1993)
卷期:
Volume 43,
issue 1‐2
页码: 44-54
ISSN:1320-5463
年代: 1993
DOI:10.1111/j.1440-1827.1993.tb02913.x
出版商: Blackwell Publishing Ltd
关键词: large cell lymphoma;large cell anaplastic lymphoma;MALT lymphoma;mediastinal lympho;mathymus
数据来源: WILEY
摘要:
We studied the morphologic, immunologic and clinical features of 14 cases of primary non‐lymphoblastic non‐Hodgkin's lymphomas of the mediastinum. The patients ranged in age from 3 to 76 years, with a median age of 28 years. According to the Ann Arbor classification, 71 % of our cases were in an early stage. Three cases were in Stage I, eight in Stage II, one in Stage III and two in Stage IV (one with multiple hepatic lesions and another with bone marrow involvement). The patients were heterogeneous in terms of the disease and were therefore histologically classified into three categories: diffuse large B cell lymphoma with sclerosis (DLS;n= 8); large cell anaplastic lymphoma (LC‐Ana; n = 5); and low grade B cell lymphoma of mucosa‐associated lym‐phoid tissue (MALT lymphoma;n= 1). DLS was the most common group and was characterized as CD5, CD10–, CD19+, CD20+, CD21‐ and CD22+. Imprint smears showed azurophilic granules in the cytoplasm of the tumor cells of three of four DLS cases. All of the six cases examined were negative when tested for Epstein‐Bart virus (EBV) sequences after hybridization with the EBV internal repeat probe. DLS and MALT lymphoma cases were of a B‐lineage lymphoma of the thymus, while most of the LC‐Ana cases were of a T‐lineage lymphoma. Patients with non‐lymphoblastic non‐Hodgkis'n lymphomas had a relatively favorable prognosis compared with lymphoblastic lymphoma (P0.05 by t
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