Influence of Tetrachlorodecaoxide (Ryoxon®) on the Development of Leukemia after Total-Body Gamma-Irradiation
作者:
Susanne R. Kempf,
Klaus Blaszkiewitz,
Rüdiger E. Port,
Stan Ivankovic,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 6
页码: 510-514
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227395
出版商: S. Karger AG
关键词: Tetrachlorodecaoxide;Ryoxon®;Total-body irradiation;γ-Rays;Prevention of leukemia;Survival rate
数据来源: Karger
摘要:
The effect of tetrachlorodecaoxide (TCDO) treatment after total-body irradiation (TBI) with γ-rays (single dose, about LD 50) on the development of radiation-induced leukemia was tested in rats. TCDO was applied intravenously from day 4 through day 11. The control group was exposed to the same dosage of X-rays (TBI), but received physiological saline solution instead of TCDO. Compared to the control group, TCDO therapy initially markedly increased the survival rate: 72 versus 44% (6 months after TBI) and 36 versus 20% (1-year survival rate). The overall survival, however, was not significantly prolonged. TBI caused leukemia in 36% of the rats in the irradiation control group without TCDO treatment, however, none of 24 rats treated with TCDO after X-ray exposure developed leukemia. Since in this study TCDO was only administered for 8 days during the acute phase of radiation syndrome, we suppose that additional TCDO treatment at various times later on would lead to even better results
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