CNS depressant effects, anti‐inflammatory activity and anti‐cholinergic actions ofSantolina chamaecyparissusextracts
作者:
R. M. Giner,
J. L. Ríos,
A. Villar,
期刊:
Phytotherapy Research
(WILEY Available online 1988)
卷期:
Volume 2,
issue 1
页码: 37-41
ISSN:0951-418X
年代: 1988
DOI:10.1002/ptr.2650020106
出版商: John Wiley&Sons, Ltd.
关键词: Santolina chamaecyparissus;effect on metabolism;analgesic action;anti‐inflammatory, anti‐ulcer effect
数据来源: WILEY
摘要:
AbstractThe pharmacological activity of several extracts together with the lyophilized infusion ofS. chamaecyparissusssp.squarrosawere investigated. The lethal dose 50% (LD50), effect on animal metabolism, mechanical and thermic analgesia and spontaneous, anti‐inflammatory, and anti‐ulcer activity have been determined. Studies on isolated organs (rat duodenum and rat uterus) were also carried out. The hexanic and chloroformic extracts were potent antagonists of the thermic analgesia test; the former extract was also active in the mechanical analgesia test. The chloroformic extract and, to a lesser extent, the ethyl acetate extract and lyophilized infusion demonstrated noteworthy activity as anti‐inflammatory agents. No extract produced an ulcerogenic effect. The hexanic extract had the highest inhibitory effect on ACh induced contraction of rat duodenum and the ethyl acetate extract of oxytocin induced contraction of rat u
点击下载:
PDF
(430KB)
返 回