AbstractExamination of biopsy samples from 62 patients with – or with suspected – cutaneous T‐cell lymphoma (CTCL) revealed 2 cases in which the neoplastic cells were positive for the T‐cell receptor (TCR) γδ complex. One patient had mycosis fungoides and 1 patient had a pleomor‐phic lymphoma of medium and large‐cell type. Both cases showed aggressive courses with dissemination to internal organs and short survival times. The phenotypic examination showed that the neoplastic cells were positive with TCRδ1, CD3, CD25, CD29, CD45RO and CD54. No staining was seen with antibodies against framework determinants or variable regions on the TCR αβ heterodimer. Negative reactions were also seen with CD4, CD8, CD5, CD7, CD16, CD30 and CD57. It is concluded that rare CTCL express TCR γδ chains. These malignancies may originate from the TCR γδ‐positive T cells seen in normal skin, and it is possible that their recognition may be importan