Psychotropic Drug Profiles: Comparisons by Topographic Maps of Absolute Power
作者:
Richard Coppola,
W.M. Herrmann,
期刊:
Neuropsychobiology
(Karger Available online 1987)
卷期:
Volume 18,
issue 2
页码: 97-104
ISSN:0302-282X
年代: 1987
DOI:10.1159/000118400
出版商: S. Karger AG
关键词: Quantitative electroencephalography;Topography;Spectrum analysis;Psychotropic drugs;Multivariate analysis
数据来源: Karger
摘要:
In a double-blind fourfold crossover design, 11 subjects were randomly assigned to placebo, 10 mg diazepam, 75 mg amitriptyline, and 75 mg chlorpromazine. During a simple vigilance task, 12 midline and left hemisphere leads were recorded before and 3 h after drug administration. The EEG was quantified by spectrum analysis, the topographic structure displayed by brain mapping techniques, and the results compared with earlier studies which used the same design and drugs. Diazepam showed the expected increase in beta; however, fast beta was increased as much as slow beta. Amitriptyline showed an increase of slow wave power and a reduction of alpha. In contrast to earlier studies, a decrease of fast beta was found. In addition, the spatial pattern of alpha changed from an occipital to a parietal maximum. Chlorpromazine showed an increase in the theta band. In occipital regions, there was a small decrease of fast beta; however, centrally there was an increase of both slow and fast beta. These results were confirmed by a multivariate analysis of variance.
点击下载:
PDF
(1687KB)
返 回