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A Pool of Native Alpha-Chains in Guinea Pig Reticulocytes

 

作者: Theresa Campana,   Simeon Pollack,   Ronald L. Nagel,  

 

期刊: Acta Haematologica  （Karger Available online 1982）
卷期: Volume 67, issue 3  

页码: 190-193

 

ISSN:0001-5792

 

年代: 1982

 

DOI:10.1159/000207054

 

出版商: S. Karger AG

 

关键词: Heme synthesis and transport;Nativeα-chains;Red cell metabolism;Reticulocyte iron uptake

 

数据来源: Karger

 

摘要:

Five radioactive peaks can be identified when hemolysates prepared from 59Fe-labelled guinea pig reticulocytes are subjected to molecular sieve chromatography. The third peak, hemoglobin, is followed by another heme-containmg peak eluting with an apparent molecular weight of 17,000. We now demonstrate that this 17,000 MW peak consists of α-chains. The high specific activity (59Fe/heme) of these α-chains suggests that they may be the primary site of heme entry into the hemoglobin molecul

 

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