An Artificial Circulation for the Study of Thrombolysis
作者:
J.E. Walker,
V. Flook,
D. Ogston,
期刊:
Acta Haematologica
(Karger Available online 1983)
卷期:
Volume 69,
issue 1
页码: 41-46
ISSN:0001-5792
年代: 1983
DOI:10.1159/000206837
出版商: S. Karger AG
关键词: Artificial circulation;Thrombolysis;Tissue activator;Urokinase
数据来源: Karger
摘要:
The construction of an artificial circulation for the study of thrombolysis allowing variation in fluid pressure and flow rate is described. The lysis of 125I-fibrin was not influenced by variation in pressure between 10 and 30 cm H2O, but was significantly faster at a flow rate of 25 ml/min than at 40 ml/min or 10 ml/min. At equivalent concentrations as assessed on fibrin plates tissue activator induced greater thrombolysis than urokinase. Thrombolysis by both activators was diminished in the presence of plasma.
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