Plasma and erythrocyte lipids in sickle cell anaemia
作者:
J. SASAKI,
M.R WATERMAN,
G.R BUCHANAN,
G.L COTTAM,
期刊:
Clinical&Laboratory Haematology
(WILEY Available online 1983)
卷期:
Volume 5,
issue 1
页码: 35-44
ISSN:0141-9854
年代: 1983
DOI:10.1111/j.1365-2257.1983.tb00494.x
出版商: Blackwell Publishing Ltd
关键词: plasma lipids;erythrocyte lipids;sickle cell anaemia
数据来源: WILEY
摘要:
Summary.The content and composition of plasma and erythrocyte lipids from individuals having sickle cell anaemia has been determined. The plasma contains a significantly reduced content of both cholesterol and phospholipid while the ratio of cholesteryl ester to total cholesterol, the distribution of phospholipids classes, triglyceride concentration and the fatty acid content were similar to normal values. However, the free glycerol content of the plasma was eight‐fold higher than normal. Erythrocyte lipids contain an elevated level of cholesterol and control levels of phospholipid content, phospholipid distribution and fatty acid content. The plasma was separated by ultracentrifugation into VLDL (density<1.006), LDL (1.006
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