The first record of some fishes(Pimelodussp., Doradidae indet.,Hoplias malabaricusandSymbranchus marmoratus)and mammals (Caviacf.apereaandMyocastor coypus)in Santiago del Estero Province, Argentina, is described. It is also mentioned cf.Hoplosternum, Prochiloduscf.platensis(Teleostei), andHolochilus chacarius(Rodentia), vertebrates unknown in the area. The faunistic material came from an archaeological site occupiedca.1000–1200 AD.