Local Pulmonary Activation of Proteolytic Enzymes afterEscherichia-coli-Induced Lung Injury in Sheep
作者:
S. Andreasson,
L. Smith,
A.O. Aasen,
T. Saldeen,
B. Risberg,
期刊:
European Surgical Research
(Karger Available online 1988)
卷期:
Volume 20,
issue 5-6
页码: 289-297
ISSN:0014-312X
年代: 1988
DOI:10.1159/000128776
出版商: S. Karger AG
关键词: Coagulation;Cascade systems;Kallikrein-kinin;Lung injury;Prostanoids
数据来源: Karger
摘要:
Activation of several cascade systems, e.g. coagulation, fibrinolysis, kallikrein-kinin, complement and eicosanoid systems, has been implicated in the etiology of septic-lung microvascular injury. A chronic lung lymph fistula preparation in sheep (n = 9) was used to study coagulation, kallikrein-kinin and eicosanoids during Escherichía coli septicemia. Lung lymph flow and lymph composition indicated an increased lung microvascular permeability approximately 2 h after infusion of bacteria. Stable prothrombin and antithrombin III levels in lymph contradicted local activation of the coagulation cascade in the lung and systemic activation was not evident until 4 h after bacteria infusion. Lymph thromboxane B2 and 6-keto PGF1α peaked early (1 h). Reduced lymph prekallikrein and kallikrein inhibitors indicated local activation of this system in the lung. Systemic activation of kallikrein could not be demonstrated. Thus, (1) changes in systemic blood may not adequately reflect local events and (2) studies of proteolytic enzymes and other inflammatory mediators in lung may contribute to clarifying the etiology of microvascular injur
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