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Amplification of the human putative oncogene INT1 in primary retinoblastoma tumors

 

作者: K. Arheden,   N. Tommerup,   N. Mandahl,   S. Heim,   J. Winther,   O.A. Jensen,   J.U. Prause,   F. Mitelman,  

 

期刊: Cytogenetic and Genome Research  （Karger Available online 1988）
卷期: Volume 48, issue 3  

页码: 174-177

 

ISSN:1424-8581

 

年代: 1988

 

DOI:10.1159/000132619

 

出版商: S. Karger AG

 

数据来源: Karger

 

摘要:

We report the amplification of the putative oncogene INTl in two of four retinoblastomas. In one case, the INTl signal was amplified 10 to 15-fold, in the other 100-fold. In both cases there were signs of increased tumor aggressiveness with invasion of the choroid and development of metastases. The two cases without INTl amplification had neither metastases nor locally invasive growth. Our findings indicate that INTl amplification may be a feature of increased malignant potential in retinoblastomas.

 

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