Differential suppression of experimental allergic diseases in rats infected with trypanosomes
作者:
A.R. MACKENZIE,
P.R. SIBLEY,
B.P. WHITE,
期刊:
Parasite Immunology
(WILEY Available online 1979)
卷期:
Volume 1,
issue 1
页码: 49-59
ISSN:0141-9838
年代: 1979
DOI:10.1111/j.1365-3024.1979.tb00695.x
出版商: Blackwell Publishing Ltd
关键词: trypanosomes;immunosuppression;adjuvant disease;EAE;delayed type hypersensitivity
数据来源: WILEY
摘要:
SummaryPVG/c rats, infected 3 days previously with 103Trypanosoma brucei brucei S.42 organisms failed to develop adjuvant disease in response to an intradermal inoculation of mycobacterial adjuvant. By contrast, similarly infected rats, immunized with heterologous brain and spinal cord in Freund's complete adjuvant with pertussis vaccine as a secondary adjuvant, developed clinical signs of allergic encephalomyelitis (EAE) at least as severe as those in uninfected rats.Delayed hypersensitivity reactions to PPD were depressed in trypanosome‐infected, adjuvant‐injected rats, as were the reactions to myelin basic protein in infected rats developing EAE. There appeared to be no cross‐reactivity between trypanosomal antigen and myelin basic protein which could account for the lack of suppression of EAE.It is suggested that the different extent to which autoimmunity is involved in these two experimental allergic diseases may account for the differential suppressive activity of trypanosome infections upon
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