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Tetracycline inequivalence: the importance of 96-hour testing

 

作者: CHARLES DAVIS,   JULES VANDERSARL,   ERIC KRAUS,  

 

期刊: The American Journal of the Medical Sciences  （OVID Available online 1973）
卷期: Volume 265, issue 1  

页码: 69-74

 

ISSN:0002-9629

 

年代: 1973

 

出版商: OVID

 

关键词: Antibiotics;Generic equivalence;Bioavailability;Tetracycline

 

数据来源: OVID

 

摘要:

Present regimens for determining the bioavailability of tetracycline antibiotics may be inadequate. When blood and urine levels of tetracycline HCI were monitored throughout a 96-hour treatment period, film-coated tetracycline tablets used in this study were found to be inferior to tetracycline capsules. This important difference would have been missed if the usual six-hour single-dose observations had been performed.

 

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