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Tamm-Horsfall Protein Accumulation in Glomeruli during Acetazolamide-Induced Acute Renal Failure

 

作者: Jérôme Rossert,   Eric Rondeau,   Guillaume Jondeau,   Pierre Ronco,   Béatrice Mougenot,   Alain Kanfer,   Jean Daniel Sraer,  

 

期刊: American Journal of Nephrology  （Karger Available online 1989）
卷期: Volume 9, issue 1  

页码: 56-57

 

ISSN:0250-8095

 

年代: 1989

 

DOI:10.1159/000167936

 

出版商: S. Karger AG

 

关键词: Acetazolamide;Tubular obstruction;Tamm-Horsfall protein;Acute renal failure

 

数据来源: Karger

 

摘要:

A patient with ocular hypertension was treated with acetazolamide. Acute renal failure developed rapidly and renal biopsy showed mild tubular lesions and crystal formation in a tubular lumen. By immunofluorescence studies with a monoclonal antibody, Tamm-Horsfall protein, normally absent from the proximal segments of the nephron, was detected in most glomeruli. This strongly suggests that tubular obstruction plays a major part in some cases of acetazolamide-induced acute renal failure.

 

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