Oxytetracycline hydrochloride in the horse: serum, synovial, peritoneal and urine concentrations after single dose intravenous administration
作者:
MURRAY P. BROWN,
SUSAN M. STOVER,
ROBIN H. KELLY,
THOMAS B. FARVER,
HUMPHREY D. KNIGHT,
期刊:
Journal of Veterinary Pharmacology and Therapeutics
(WILEY Available online 1981)
卷期:
Volume 4,
issue 1
页码: 7-10
ISSN:0140-7783
年代: 1981
DOI:10.1111/j.1365-2885.1981.tb00703.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Six adult mares were given a single intravenous injection of oxytetracycline HCl (50 mg/ml) at a dosage of 5 mg/kg. Serum, synovial fluid, peritoneal fluid, and urine oxytetracycline concentrations were measured serially over a 48‐h period. The highest measured serum oxytetracycline concentration was 8.01 mcg/ml at 1/2 h. Oxytetracycline was detected in synovial fluid and peritoneal fluid, which obtained mean peak oxytetracycline concentrations of 4.43 mcg/ml and 4.20 mcg/ml, at 1/2 h and 1 h, respectively. These concentrations steadily declined in parallel with serum concentrations and were not measurable at 48 h. Urine oxytetracycline concentration was relatively high, with a peak concentration of 1565.2 mcg/ml at 1/2 h after drug administratio
点击下载:
PDF
(275KB)
返 回