Antibacterial Activity of TOC-50, a New Parenteral Cephalosporin against Penicillin-Susceptible and Penicillin-ResistantStreptococcus pneumoniae
作者:
Shuichi Nomura,
Hideaki Hanaki,
Tetsuo Furukawa,
Norio Unemi,
期刊:
Chemotherapy
(Karger Available online 1997)
卷期:
Volume 43,
issue 1
页码: 1-5
ISSN:0009-3157
年代: 1997
DOI:10.1159/000239527
出版商: S. Karger AG
关键词: TOC-50;Penicillin-resistant;Streptococcus pneumoniae Cephalosporins
数据来源: Karger
摘要:
TOC-50, a new parenteral cephalosporin, was assessed for antibacterial activity in vitro and in vivo. In vitro, the activity of TOC-50 was greater than ampicillin, erythromycin and gentamycin, and was equal to that of imipenem. The MICs of TOC-50 for 90% of the clinical isolates tested (MIC90 values) were 0.0125 μg/ml for penicillin-susceptible Streptococcus pneumoniae, 0.2 μg/ml for intermediately penicillin-resistant S. pneumoniae, and 0.39 μg/ml for fully penicillin-resistant S. pneumoniae. In murine systemic-infection models, TOC-50 had a potent protective activity against penicillin-susceptible or fully penicillin-resistant S. pneumoniae. Its protective activity was stronger than that of imipen
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