HYPERTHYROIDISM DUE TO A PITUITARY TSH SECRETING TUMOUR WITH AMENORRHOEA‐GALACTORRHOEA
作者:
R. BENOIT,
B. E. PEARSON‐MURPHY,
F. ROBERT,
S. MARCOVITZ,
J. HARDY,
G. TSOUKAS,
R. J. GARDINER†,
期刊:
Clinical Endocrinology
(WILEY Available online 1980)
卷期:
Volume 12,
issue 1
页码: 11-19
ISSN:0300-0664
年代: 1980
DOI:10.1111/j.1365-2265.1980.tb03127.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYA 20–year‐old female presented with thyrotoxicosis associated with amenorrhoea and galactorrhoea after oral contraceptive withdrawal. Serum TSH was persistently elevated (mean: 28 ± 31 μU/ml during 24–h sampling and did not vary significantly after TRH, bromocriptine or somatostatin. Prolactin levels remained constantly at the upper limit of normal (mean: 206 ± 21 ng/ml, with a minimal increase after TRH, a slight decrease after somatostatin (54%) and a marked decrease after bromocriptine (885%). Surgical exploration revealed an unusually firm tumour adherant to the wall of the sella turcica; electron microscopic study showed that it was composed almost exclusively of thyrotrophs. After a transient period of euthyroidism post‐operatively, T3 toxicosis occurred with an increased TSH level (155 μU/ml) and a rise in TSH and alpha subunit in response to TRH. An increase in T4 followed while prolactin r
点击下载:
PDF
(942KB)
返 回