Hypermagnesiuria in Children with Newly Diagnosed Insulin-Dependent Diabetes mellitus
作者:
Marco Roffi,
Christina Kanaka,
Primus-E. Mullis,
Edgar Peheim,
Mario G. Bianchetti,
期刊:
American Journal of Nephrology
(Karger Available online 1994)
卷期:
Volume 14,
issue 3
页码: 201-206
ISSN:0250-8095
年代: 1994
DOI:10.1159/000168715
出版商: S. Karger AG
关键词: Acid-base imbalance;Diuresis;Insulin-dependent diabetes mellitus;Magnesium deficiency
数据来源: Karger
摘要:
In newly diagnosed insulin-dependent diabetes mellitus, the mechanisms underlying the concomitant occurrence of magnesium deficiency and normal blood magnesium concentration are unknown. The renal handling of magnesium was, therefore, studied in 37 children with newly diagnosed insulin-dependent diabetes mellitus and in 13 controls. Circulating magnesium levels were similar in patients and controls (0.86 vs. 0.84 mmol/l). However, the urinary excretion of magnesium was significantly higher in patients (90.6 vs. 32.2 µmol/l GFR). In the patients a significant positive correlation was found between excretion of magnesium and glycosuria or blood hydrogen ion activity. It is concluded that osmotic diuresis and acidosis increase magnesium excretion in newly diagnosed diabetes mellitus
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