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Effects of a Large Dose of Retinol or Retinoic Acid on the Thyroid Hormones in the Rat

 

作者: Henri Garcin,   Paul Higueret,   Kouakou Amoikon,  

 

期刊: Annals of Nutrition and Metabolism  (Karger Available online 1984)
卷期: Volume 28, issue 2  

页码: 92-100

 

ISSN:0250-6807

 

年代: 1984

 

DOI:10.1159/000176788

 

出版商: S. Karger AG

 

关键词: Hypervitaminosis A;Retinol;Retinoic acid;Thyroxine;Triiodothyronine;Thyroid hormone turnover

 

数据来源: Karger

 

摘要:

The daily food intake of a large dose of retinol (as palmitate) or retinoic acid (as all-trans retinoic acid) modifies numerous parameters of the thyroidal status in the rat. There were decreases of the serum total thyroxine (TT4) and triiodothyronine (TT3), and of the biological half-life of T4, while there were increases of the dialyzable fractions of T4 and T3 and of the apparent distribution space of T3. The possible causes of these changes are discussed.

 

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