Influence of doxorubicin on rat incisor mesenchymal cells
作者:
JON EINAR DAHL,
期刊:
European Journal of Oral Sciences
(WILEY Available online 1984)
卷期:
Volume 92,
issue 1
页码: 6-13
ISSN:0909-8836
年代: 1984
DOI:10.1111/j.1600-0722.1984.tb00853.x
出版商: Blackwell Publishing Ltd
关键词: antineoplastic agents;dental pulp;dentinogenesis;histology;odontoblasts;odontogenesis
数据来源: WILEY
摘要:
Abstract –Three groups of female Wistar rats were intravenously injected with the antineoplastic drug doxorubicin in a single dose of 5 mg/kg, 10 mg/kg and 20 mg/kg, respectively. The animals were killed 1 and 5 days after injection. Paraffin and Vestopal W embedded sections were prepared of the maxillary right and left incisors, respectively, and evaluated by light microscopy. Doxorubicin produced necrosis of single cells, of small groups of cells in the basal pulp and destroyed the preodontoblasts as evaluated 1 day after injection. On the 5th day of observation, the late preodontoblasts and basal pulp had regenerated, but the early preodontoblast zone remained absent, leading to an abnormal odontogenesis. This caused a marked reduction of dentin deposition in the apical part of the tooth and production of irregular predentin by cells in the pulp and by the young odontoblast
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