Lymphocyte Responsiveness to Urinary Glycosaminoglycan in Systemic Scleroderma
作者:
Hidekazu Ishikawa,
Akira Hattori,
期刊:
Dermatology
(Karger Available online 1979)
卷期:
Volume 158,
issue 5
页码: 328-333
ISSN:1018-8665
年代: 1979
DOI:10.1159/000250776
出版商: S. Karger AG
关键词: Cellular immunity;Glycosaminoglycan;Systemic scleroderma
数据来源: Karger
摘要:
From the urine of patients with systemic scleroderma, we previously isolated a glycosaminoglycan, which could induce a scleroderma-like change in the skin of mouse. In the present work, the cell-mediated response to urinary glycosaminoglycans was examined by lymphocyte transformation test. The specific response was observed in lymphocytes of patients with scleroderma, when the above scleroderma-inducing glycosaminoglycan was added. By contrast, lymphocytes of patients with SLE or dermatomyositis and of normal persons hardly showed a response to this glycosaminoglycan. On the other hand, the glycosaminoglycans from normal urine could not stimulate lymphocytes of patients with scleroderma or healthy persons.
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