Genetic Control of Macrophage Activation for Killing of Extracellular Targets
作者:
Emil Skamene,
Stephanie L. James,
Monte S. Meltzer,
Muriel N. Nesbitt,
期刊:
Journal of Leukocyte Biology
(WILEY Available online 1984)
卷期:
Volume 35,
issue 1
页码: 65-69
ISSN:0741-5400
年代: 1984
DOI:10.1002/jlb.35.1.65
出版商: Wiley
数据来源: WILEY
摘要:
Activated peritoneal macrophages from Corynebacterium parvum‐treated mice of most inbred strains, including C57BL/6J (B), are cytotoxic to adherent 1023 sarcoma target cells as well as to larvae of Schistosoma mansoni. Macrophages from A/J (A) strain mice, on the other hand, are defective in this function. Segregation analysis of these two traits was compatible with the hypothesis that effective activation is, in each case, controlled by a single, dominant, autosomal gene. Typing of individual animals of the segregating backcross progeny and of AXB/BXA recombinant inbred strains for the expression of macrophage activation for tumoricidal and schistosomulicidal activity indicates that the genetic control of these two traits is closely linked or identical.
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