Mutant Alleles at the Locus elav in Drosophila melanogaster lead to Nervous System Defects. A Developmental-Genetic Analysis
作者:
CamposAna Regina,
AndDina Grossman,
WhiteKalpana,
期刊:
Journal of Neurogenetics
(Taylor Available online 1985)
卷期:
Volume 2,
issue 3
页码: 197-218
ISSN:0167-7063
年代: 1985
DOI:10.3109/01677068509100150
出版商: Taylor&Francis
关键词: Key words:neural defect–;Drosophila melanogaster–;genetic mosaics–;visual development
数据来源: Taylor
摘要:
We report a developmental and genetic analysis of the X-linked vital locusl(1)EC7inDrosophila melanogaster. The locus maps in the salivary band region 1B4-5 to 1B8-9, a part of the X chromosome previously shown to be essential for normal neural development. Certain mutant alleles at the locus can cause embryonic lethality, indicating that the function provided by the gene is essential during embryo-genesis. A developmental analysis of gynandromorphic genetic mosaics shows that: (l)the gene function is autonomously essential in the eye; (2) the gene function is essential for normal development of the optic lobes; and (3) the gene function is not necessary in most major imaginal-disc cell derivatives with the exception of the eye disc. Conclusions from the developmental analysis of a temperature sensitive allele are consistent with those from the mosaic analysis. The embryonic lethality caused by the mutant alleles and abnormalities observed in the genetic mosaics have led us to rename the locusl(1)EC7toelav(embryonic lethal, abnormal visual system).
点击下载:
PDF (1442KB)
返 回