Central (aortic or subclavian), brachial, radial and femoral pressure pulses were recorded simultaneously in 12 healthy subjects during conditions of rest, exercise and 70 degree head-up tilt. Peripheral systolic pressure at rest uniformly exceeded the central systolic pressure generated by the same heartbeat. The average radial pulse pressure was 146, 146 and 165 per cent of central pulse pressure during rest, exercise and tilt while radial mean pressures were 94, 93 and 98 per cent of central mean pressures respectively. Summation of the incident pulse wave with reflected waves from the periphery and resonance effects in the peripheral arterial systems may produce these changes in pressure and contour.