The histopathology and ultrastructure of liver disease in erythropoietic protoporphyria
作者:
D.M. MACDONALD,
DANIELE GERMAIN,
H. PERROT,
期刊:
British Journal of Dermatology
(WILEY Available online 1981)
卷期:
Volume 104,
issue 1
页码: 7-18
ISSN:0007-0963
年代: 1981
DOI:10.1111/j.1365-2133.1981.tb01705.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYThe light, polarization and electron microscopic changes in the liver of four cases of erythropoietic protoporphyria (EPP) are described. In one of these cases liver involvement resulted in death, whereas in the other three there were no symptoms referable to hepatic disease. In two cases hepatic pigment was readily visible on light and polarization microscopy and corresponded to characteristic crystalline aggregates seen ultrastructurally. Pronounced micronodular cirrhosis and cholestasis were present in the fatal case, while in the other only mild periportal fibrosis and mononuclear inflammatory cell infiltrate occurred. The third and fourth cases showed no evidence of hepatic involvement on light microscopy. Electron microscopy, however, revealed characteristic crystal‐containing vacuoles indicative of protoporphyrin deposition. The need for early detection of the hepatic lesion is emphasize
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