Treatment of Acne vulgaris with the Retinoic Acid Derivative Ro 11-1430
作者:
Jørgen Christiansen,
Per Holm,
Flemming Reymann,
期刊:
Dermatology
(Karger Available online 1976)
卷期:
Volume 153,
issue 3
页码: 172-176
ISSN:1018-8665
年代: 1976
DOI:10.1159/000251112
出版商: S. Karger AG
关键词: Ro 11-1430;Retinoic acid;Acne;Side-effects
数据来源: Karger
摘要:
In a double-blind, randomized, group-comparative clinical trial, 31 patients with acne vulgaris received topical treatment for 6-8 weeks with a lotion containing either 0.05% retinoic acid or 0.1 % of the retinoic acid derivative Ro 11-1430. The side-effects erythema, desquamation and burning were significantly less frequent with Ro 11-1430 than with retinoic acid. The treatments appeared to be approximately equally effective in reducing the number of acne elements, but due to the limited number of patients studied, the trial was admittedly not sufficient to detect differences with regard to therapeutic efficacy.
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