Nephrotoxicity Associated with Use of Methoxyflurane
作者:
Eugene G.C. Wong,
Peter H. Rowe,
Michael J. Blumenkrantz,
Jack W. Coburn,
期刊:
Nephron
(Karger Available online 1974)
卷期:
Volume 13,
issue 2
页码: 174-182
ISSN:1660-8151
年代: 1974
DOI:10.1159/000180390
出版商: S. Karger AG
关键词: Fluoride compound;inorganic;Acute renal failure;Methoxyflurane;Anesthesia;Nephrotoxic agent
数据来源: Karger
摘要:
Two cases of severe renal failure associated with the use of methoxyflurane anesthesia are reported. Both patients had polyuria during the immediate period after anesthesia and 7–10 days later became oliguric. After 26–31 days, a diuresis occurred with very slow recovery of adequate but reduced renal function. One case demonstrated hypernatremia and hyperosmolality. The development of renal failure did not depend upon a prolonged period of anesthesia. In one case, a renal biopsy revealed tubular epithelial cell degeneration, necrosis, and atrophy and crystals resembling calcium oxalate. Multiple mechanisms which may contribute to the development of renal failure associated with methoxyflurane are discussed. Supportive therapy, including dialysis, seems warranted to allow adequate time for return of renal funct
点击下载:
PDF
(1074KB)
返 回