Metabolism of oxidized LDL by macrophages
作者:
Wendy Jessup,
Leonard Kritharides,
期刊:
Current Opinion in Lipidology
(OVID Available online 2000)
卷期:
Volume 11,
issue 5
页码: 473-481
ISSN:0957-9672
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
Oxidation products of lipids and proteins are found in atherosclerotic plaque and in macrophage foam cells. Macrophages avidly endocytose in-vitro oxidized LDL and accumulate sterols. What is the evidence that such a process is involved in in-vivo foam cell formation? The present review surveys current knowledge on the metabolism of oxidized LDL by macrophages, and the types, amounts and location of oxidation products that accumulate in these cells. Comparable studies of lesion lipoproteins and foam cells indicate that limited extracellular lipoprotein oxidation, perhaps followed by more extensive intracellular oxidation subsequent to uptake by macrophages, is a more likely scenarioin vivo.
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