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Immunization of Mice with a Mutant ofCryptococcus neoformans

 

作者: Frederick Reiss,   Erna Alture-Werber,  

 

期刊: Dermatology  （Karger Available online 1976）
卷期: Volume 152, issue 1  

页码: 16-22

 

ISSN:1018-8665

 

年代: 1976

 

DOI:10.1159/000251156

 

出版商: S. Karger AG

 

关键词: Cryptococcus neoformans;Cryptococcosis;Cobalt radiation;Non-pathogenic mutant;Immunization

 

数据来源: Karger

 

摘要:

In 69% of subdermally and 50% of subcutaneously immunized mice, immunity against Cryptococcus neoformans was obtained. The vaccine consisted of a γ-irradiated mutant, which grew well at 5 °C and at room temperature. Many subcultures and animal passages did not restore this mutant to the encapsulated, pathogenic wild typ

 

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