AbstractAimTo investigate the outcome of therapeutic ovarian hormones on concurrent aphthous stomatitis.BackgroundStudies of therapeutic hormones in recurrent aphthous stomatitis have shown conflicting results, mostly not amenable to statistical analysis.Methods114 clients attending a well woman clinic were evaluated by means of a structured interview.ResultsWomen with menstrual cycle associated aphthae were more likely to have complete or partial remission when receiving therapeutic ovarian hormones; women with menstrual cycle unassociated aphthae were more likely to have no change or exacerbation. These differences were statistically significant (p<0.001).ConclusionsThe findings are consistent with the postulated role of ovarian hormones in the aetiology of menstrual cycle associated aphthous stomatitis.