Eicosanoid Release in Polymorphous Light Eruption: Selective UV-A-Induced LTB4Generation by Peripheral Blood Leukocytes
作者:
Thomas Ruzicka,
Bernhard Przybilla,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1988)
卷期:
Volume 1,
issue 3
页码: 186-191
ISSN:1660-5527
年代: 1988
DOI:10.1159/000210772
出版商: S. Karger AG
关键词: Polymorphous light eruption;Ultraviolet A, B;Leukotriene B4;Prostaglandin E2
数据来源: Karger
摘要:
The biochemical basis of ultraviolet-induced cutaneous inflammation in polymorphous light eruption (PLE) is not known. We investigated the potential role of eicosa-noids – derivatives of arachidonic acid – as mediators of inflammation in this common disorder. 13 patients were investigated, in whom skin lesions could be experimentally reproduced by repeated UV-A but not UV-B irradiation. Peripheral blood leukocytes of these patients were irradiated with UV-A or UV-B, and the release of leukotriene B4 (LTB4), LTC4 and prostaglandin E2 (PGE2) was measured. Cells from PLE patients, but not healthy controls, released selectively high amounts of LTB4 in response to UV-A. The UV-A-induced LTB4 release was light-dose-dependent. This phenomenon was not observed with UV-B. The selective UV-A-induced release of LTB4 could play a major role in the pathophysiology of cutaneous inflammation in PLE.
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