Prognostic Value of T Lymphocyte Subset Ratio in Idiopathic Membranous Nephropathy
作者:
Pietro Zucchelli,
Claudio Ponticelli,
Leonardo Cagnoli,
Adriana Aroldi,
Elisabetta Beltrandi,
期刊:
American Journal of Nephrology
(Karger Available online 1988)
卷期:
Volume 8,
issue 1
页码: 15-20
ISSN:0250-8095
年代: 1988
DOI:10.1159/000167547
出版商: S. Karger AG
关键词: T lymphocyte;Subsets;Idiopathic membranous nephropathy;Cell-mediated immunity;Nephropathy
数据来源: Karger
摘要:
The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.
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